Welcome to my blog :)

rss

Monday, June 17, 2013

Scientific Basis for Ayurvedic Therapies -10







































































Scientific Basis for
Ayurvedic Therapies 


edited by
Brahmasree Lakshmi Chandra Mishra




References

1. Crawford, J.M. and Cotran, R.S., The pancreas, in Robins Pathological Basis of Disease, Cotran,
R.S., Kumar, V., and Collins, T., Eds., W.B. Saunders, New York, 1999, chap. 20.
2. Sherwin, R.S., Diabetes mellitus, in Cecil Textbook of Medicine, Goldman, L. and Bennett, J.C.,
Eds., W.B. Saunders, New York, 2000, chap. 242.
3. Davis, S.N. and Granner, D.K., Insulin, oral hypoglycemic agents, and the pharmacology of
the endocrine pacreas, in Goodman & Gillman’s The Pharamcological Basis of Therapeutics, Hardman,
J.L., Limbird, L.E., Molinoff, P.B., Ruddon, R.W., and Gilman, A.G., Eds., McGraw-Hill,
New York, 1995, chap. 60.
4. Sharma, P.V., Caraka Samhita, 4th ed., Chaukhambha Orientalia, Varanasi, India, 1998, p. 120.
5. Kyvik, K.O., Green, A., and Beck-Nielsen, H., Concordance rates of insulin dependent diabetes
mellitus: a population based study of young Danish twins, Br. Med. J., 312(7026), 913, 1996.
6. Bain, S.C. et al., Genetic factors associated with insulin-dependent diabetes, Front. Horm. Res.,
22, 23, 1997.
7. Grewal, I.S. and Flavell, R.A., New insight into insulin dependent diabetes mellitus from
studies with transgenic mouse models, Lab. Invest., 76, 3, 1997.
8. Zekzer, D. et al., GAD reactive CD4+Th 1 cells induce diabetes in NOD/SCJD mice, J. Clin.
Invest., 101, 68, 1998.
9. Verge, C.F. et al., Number of autoantibodies (against insulin, GAD or ICA512/IA) rather than
particular antibody determines risk of type 1 diabetes, J. Autoimmunol., 9, 379, 1996.
10. Bharti, M.S. and Singh, R.H., Constitutional study of patients of diabetes mellitus vis-à-vis
Madhumeha, Ancient Sci. Life, 15(1), 35, 1995.
11. Chandola, H.M., Tripathi, S.N., and Udupa, K.N., Variations in the progression of maturity
onset diabetes according to body constitution, Ancient Sci. Life, 13(3–4), 293, 1994.
12. Kar, C.A., Upadhyay, B.N., and Ojha, D., Prognosis of prameha on the basis of insulin level,
Ancient Sci. Life, 16, 277, 1997.
13. Ashtang Hradayam, translated by Srikantha Murthy K.R., Krishnadas Academy, Varanasi 1,
UP. India, 1998.
14. University group diabetes program: a story of the effects of hypoglycemic agents on vascular
complications in patients with adult-onset diabetes. II. Motality results, Diabetes, 19, 789, 1970.
15. Bone, K., Gymnema sylvester, in Clinical Applications of Ayurvedic and Chinese Herbs: Monographs
for the Western Herbal Practitioner, Bone, K., Ed., Phytotherapy Press, Warwick Queensland,
Australia, 1996.
16. Shanmugasundaram, K.R., Panneerselvam, C., Samudram, P., et al., The insulinotropic activity
of Gymnema sylvestre, R.Br. and Indian medical herb used in controlling diabetes mellitus,
Pharmcol. Res. Commun., 13(5), 475, 1981.
17. Shanmugasundaram, K.R., Panneerselvam, C., Samudram, P., et al., Enzyme changes and
glucose utilization in diabetic rabbits: the effect of Gymnema sylvestre, R Br., J. Ethnopharmacol.,
7(2), 205, 1983.
18. Shanmugasundaram, E.R., Venkatasubrahmanyam, M., Vijendran, N., et al., Effect of an isolate
from Gymnema sylvestre, R.Br. in control of diabetes mellitus and the associated pathological
changes, Ancient Sci. Life, 7(3–4), 183, 1988.
19. Shanmugasundaram, E.R., Gopinath, K.L., Radha Shanmugasundaram, K.R., et al., Possible
regeneration of the islets of Langerhans in streptozocin-diabetic rats given Gymnema sylvestre
leaf extracts, J. Ethnopharmacol., 30, 265, 1990.
20. Sugihara, Y., Nojima, H., Matsuda, H., et al., Antihyperglycemic effects of gymnemic acid IV,
a compound derived from Gymnema sylvestre leaves in streptozotocin-diabetic mice, Nat. Prod.
Res., 2(4), 321, 2000.
21. Persaud, S.J., Al-Majed, H., Raman, A., et al., Gymnema sylvestre stimulates insulin release in
vitro by increased membrane permeability, J. Endocrinol., 163(2), 207, 1999.

22. Prakash, A.O., Mathur, S., and Mathur, R., Effect of feeding Gymnema sylvestre leaves on
blood glucose in beryllium nitrate treated rats, J. Ethnopharmacol., 18, 143, 1986.
23. Shanmugasundaram, E.R., Rajeswari, G., Baskaran, K., et al., Use of Gymnema sylvestre leaf
extract in the control of blood glucose in insulin-dependent diabetes mellitus, J. Ethnopharmacol.,
30(3), 281, 1990.
24. Baskaran, K., Kizar Ahamath, B.K., and Radha Shanmugasundaram, K.R., Antidiabetic effect
of a lead extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients,
J. Ethnopharmacol., 30(3), 295, 1990.
25. Srivastava, Y., Venkatakrishna-Bhatt, H., Jhala, C.I., et al., Oral Gymnema sylvestre R.Br. leaf
extracts inducing protracted longevity and hypoglycemia in alloxan induced rats: review and
experimental study, Int. J. Crude Drug Res., 24, 171, 1986.
26. Wang, L.F., Luo, H., Miyoshi, M., et al., Inhibitory effect of gymnemic acid on intestinal
absorption of oleic acid in rats, Can. J. Physiol. Pharmacol., 76(10–11), 1017, 1998.
27. Khare, A.K., Tondon, R.N., and Tewari, J.P., Hypoglycemic activity of an indigenous drug
(Gymnema sylvestre, “Gurmar”) in normal and diabetic persons, Indian J. Physiol. Pharmacol.,
27(3), 257, 1983.
28. Balasubramaniam, K., Arasaratnam, V., Seevaratnam, S., et al., Hypoglycemic effect if Gymnema
sylvestre on diabetic patients, Jaffna Med. J., 23, 49, 1988.
29. Chatterjee, A. and Pakrashi, S.C., The Treatise on Indian Medicinal Plants, Vol. 5, National
Institute of Science and Communication, New Delhi, India, 1997, p. 124.
30. Leatherdale, B.A., Panesar, R.K., Singh, G., et al., Improvement in glucose tolerance due to
Momordica charantia (karela), Br. Med. J., 282, 1823, 1981.
31. Khanna, P., Jain, S.C., Panagariya, A., et al., Hypoglycemic activity of polypeptide-p from a
plant source, J. Nat. Prod., 44(6), 648, 1981.
32. Singh, N., Tyagi, S.D., and Agarwal, S.C., Effects of long term feeding of acetone extract of
Momordica charantia (whole fruit powder) on alloxan diabetic albino rats, Indian J. Physiol.
Pharmacol., 33(2), 97, 1989.
33. Karunanayake, E.H., Jeevathayaparan, S., and Tennekoon, K.H., Effect of Momordica charantia
fruit juice on streptozotocin-induced diabetes in rats, J. Ethnopharmacol., 30(2), 199, 1990.
34. Day, C., Cartwright, T., Provost, J., et al., Hypoglycemic effect of Momordica charantia extracts,
Planta Med., 56(5), 426, 1990.
35. Higashino, H., Suzuki, A., Tanaka, Y., et al., Hypoglycemic effects of Siamese Momordica
charantia and Phyllanthus urinaria extracts in streptozotocin-induced diabetic rats (the 1st
report), Nippon Yakurigaku Zasshi, 100(5), 415, 1992.
36. Shibib, B.A., Khan, L.A., and Rahman, R., Hypoglycemic activity of Coccina indica and Momordica
charantia in diabetic rats: depression of the hepatic gluconeogenic enzymes glucose-
6-phosphatase and fructose-1,6-bisphosphatase and elevation of both liver and red-cell shunt
enzyme glucose-6-phosphate dehydrogenase, Biochem. J., 292 (Pt 1), 267, 1993.
37. Sarkar, S., Pranava, M., and Marita, R., Demonstration of the hypoglycemic action of Momordica
charantia in a validated animal model of diabetes, Pharmacol. Res., 33(1), 1, 1996.
38. Raza, H., Ahmed, I., Lakhani, M.S., et al., Effect of bitter melon (Momordica charantia) fruit
juice on the hepatic cytochrome P450-dependent monooxygenases and glutathione S-transferases
in streptozotocin-induced diabetic rats, Biochem. Pharmacol., 52(10), 1639, 1996.
39. Miura, T., Itoh, C., Iwamoto, N., et al., Hypoglycemic activity of the fruit of the Momordica
charantia in type 2 diabetic mice, J. Nutr. Sci. Vitaminol., 47(5), 340, 2001.
40. Matsuda, H., Murakami, T., Shimada, H., et al., Inhibitory mechanisms of oleanolic acid 3-Omonodesmosides
on glucose absorption in rats, Biol. Pharm. Bull., 20(6), 717, 1997.
41. Ahmed, I., Adeghate, E., Sharma, A.K., et al., Effects of Momordica charantia fruit juice on islet
morphology in the pancreas of the streptozocin-diabetic rat, Diabetes Res. Clin. Pract., 40(3),
145, 1998.
42. Matsuda, H., Li, Y., Yamahara, J., et al., Inhibition of gastric emptying by triterpene saponin,
momordin Ic, in mice: roles of blood glucose, capsaicin-sensitive sensory nerves, and central
nervous system, J. Pharmacol. Exp. Ther., 289(2), 729, 1999.
43. Sitasawad, S.L., Shewade, Y., and Bhonde, R., Role of bittergourd fruit juice in stz-induced
diabetic state in vivo and in vitro, J. Ethnopharmacol., 73(1–2), 71, 2000.

44. Ahmed, I., Lakhani, M.S., Gillett, M., et al., Hypotriglyceridemic and hypocholesterolemic
effects of anti-diabetic Momordica charantia (karela) fruit extract in streptozotocin-induced
diabetic rats, Diabetes Res. Clin. Pract., 51(3), 155, 2001.
45. Grover, J.K., Vats, V., Rathi, S.S., et al., Traditional Indian anti-diabetic plants attenuate progression
of renal damage in streptozotocin induced diabetic mice, J. Ethnopharmacol., 76(3),
233, 2001.
46. Srivastava, Y., Venkatakrishna-Bhatt, H., and Verma, Y., Effect of Momordica charantia Linn.
pomous aqueous extract on cataractogenesis in murrin alloxan diabetes, Pharmacol. Res. Commun.,
20(3), 201, 1988.
47. Raza, H., Ahmed, I., John, A., et al., Modulation of xenobiotic metabolism and oxidative stress
in chronic streptozotocin-induced diabetic rats fed with Momordica charantia fruit extract, J.
Biochem. Mol. Toxicol., 14(3), 131, 2000.
48. Baldwa, V.S., Bhandari, C.M., Pangaria, A., et al., Clinical trial in patients with diabetes mellitus
of an insulin-like compound obtained from plant source, Ups. J. Med. Sci., 82(1), 39, 1977.
49. Akhtar, M.S., Trial of Momordica charantia Linn. powder in patients with maturity onset diabetes,
J. Pak. Med. Assoc., April, 106, 1982.
50. Welihinda, J., Karunanayake, E.H., and Sheriff, M.H., Effect of Momordica charantia on the
glucose tolerance in maturity onset diabetes, J. Ethnopharmacol., 17, 277, 1986.
51. Srivastava, Y., Venkatakrishna-Bhatt, H., Verma, Y., et al., Antidiabetic and adaptogenic properties
of Momordica charantia extract: an experimental and clinic evaluation, Phytother. Res.,
7(4), 285, 1993.
52. Ahmad, N., Hassan, M.R., Halder, H., et al., Effect of Momordica charantia (Karolla) extracts
on fasting and postprandial serum glucose levels in NIDDM patients, Bangladesh Med. Res.
Counc. Bull., 25(1), 11, 1999.
53. Chatterjee, A. and Pakrashi, S.C., The Treatise on Indian Medicinal Plants, Vol. 2, Publications
and Information Directorate, New Delhi, India, 1992, p. 125.
54. Mishkinsky, J.S., Goldschmied, A., Joseph, B., et al., Hypoglycemic effect of Trigonella Foenum
graecum and Lupinus termis (leguminosae) seeds and their major alkaloids in alloxan diabetic
and normal rats, Arch. Int. Pharmacodyn. Ther., 210(1), 27, 1974.
55. Ghafghazi, T., Sheriat, H.S., Dastmalchi, T., et al., Antagonism of cadmium and alloxaninduced
hyperglycemia in rats by Trigonella foenum graecum, Pahlavi Med. J., 8(1), 14, 1977.
56. Ribes, G., Sauvaire, Y., Da Costa, C., et al., Antidiabetic effects of subfractions from fenugreek
seeds in diabetic dogs, Proc. Soc. Exp. Biol. Med., 182(2), 159, 1986.
57. Khosla, P., Gupta, D.D., and Nagpal, R.K., Effect of Trigonella foenum graecum (Fenugreek) on
blood glucose in normal and diabetic rats, Indian J. Physiol. Pharmacol., 39(2), 173, 1995.
58. Ali, L., Azad Khan, A.K., Hassan, Z., et al., Characterization of the hypoglycemic effects of
Trigonella foenum graecum seed, Planta Med., 61(4), 358, 1995.
59. Abdel-Barry, J.A., Abdel-Hassan, I.A., and Al-Hakiem, M.H., Hypoglycaemic and antihyperglycaemic
effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats,
J. Ethnopharmacol., 58(3), 149, 1997.
60. Raju, J., Gupta, D., Rao, A.R., et al., Effect of antidiabetic compounds on glyoxalase I activity
in experimental diabetic rat liver, Indian J. Exp. Biol., 37(2), 193, 1999.
61. Genet, S., Kale, R.K., and Baquer, N.Z., Effects of vanadate, insulin and fenugreek (Trigonella
foenum graecum) on creatine kinase levels in tissues of diabetic rat, Indian J. Exp. Biol., 37(2),
200, 1999.
62. Raju, J., Gupta, D., Rao, A.R., et al., Trigonellafoenum graecum (fenugreek) seed powder improves
glucose homeostasis in alloxan diabetic rat tissues by reversing the altered glycolytic, gluconeogenic
and lipogenic enzymes, Mol. Cell. Biochem., 224(1–2), 45, 2001.
63. Zia, T., Hasnain, S.N., and Hasan, S.K., Evaluation of the oral hypoglycaemic effect of Trigonella
foenum-graecum L. (methi) in normal mice, J. Ethnopharmacol., 75(2–3), 191, 2001.
64. Vats, V., Grover, J.K., and Rathi, S.S., Evaluation of anti-hyperglycemic and hypoglycemic
effect of Trigonella foenum-graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn
in normal and alloxanized diabetic rats, J. Ethnopharmacol., 79(1), 95, 2002.

65. Abdel-Barry, J.A., Abdel-Hassan, I.A., Jawad, A.M., et al., Hypoglycaemic effect of aqueous
extract of the leaves of Trigonella foenum-graecum in healthy volunteers, East. Mediterr. Health
J., 6(1), 83, 2000.
66. Sharma, R.D. and Raghuram, T.C., Hypoglycemic effect of fenugreek seed in non-insulin
dependent diabetic subjects, Nutr. Res., 10, 731, 1990.
67. Ribes, G., Sauvaire, Y., Da Costa, C., et al., Antidiabetic effects of sub fractions from fenugreek
seeds in diabetic dogs, Proc. Soc. Exp. Biol. Med., 182(2), 159, 1986.
68. Petit, P.R., Sauvaire, Y.D., Hillaire-Buys, D.M., et al., Steroid saponins from fenugreek seeds:
extraction, purification, and pharmacological investigation on feeding behavior and plasma
cholesterol, Steroids, 60(10), 674, 1995.
69. Ravikumar, P. and Anuradha, C.V., Effect of fenugreek seeds on blood lipid peroxidation and
antioxidants in diabetic rats, Phytother. Res., 13(3), 197, 1999.
70. Gupta, D., Raju, J., and Baquer, N.Z., Modulation of some gluconeogenic enzyme activities in
diabetic rat liver and kidney: effect of antidiabetic compounds, Indian J. Exp. Biol., 37(2), 196,
1999.
71. Sharma, R.D., Effect of fenugreek seeds and leaves on blood glucose and serum insulin
responses in human subjects, Nutr. Res., 6(12), 1353, 1986.
72. Sharma, R.D., Raghuram, T.C., and Rao, N.S., Effect of fenugreek seeds on blood glucose and
serum lipids in type I diabetes, Eur. J. Clin. Nutr., 44, 301, 1990.
73. Raghuram, T.C., Sharma, R.D., Sivajumar, B., et al., Effect of fenugreek seeds on intravenous
glucose disposition in non-insulin-dependent diabetic patients, Phytother. Res., 8, 83, 1994.
74. Sharma, R.D., Sarkar, A., Hazra, D.K., et al., Hypolipidaemic effect of fenugreek seeds: a
chronic study of non-insulin dependent diabetic patients, Phytother. Res., 10(4), 332, 1996b.
75. Kuppu Rajan, K., Srivatsa, A., Krishnaswami, C.V., et al., Hypoglycemic and hypotriglyceridemic
effects of methika Churna (fenugreek), Antiseptic, 95(3), 78, 1998.
76. Chatterjee, A. and Pakrashi, S.C., The Treatise on Indian Medicinal Plants, Vol. 5, National
Institute of Science and Communication, New Delhi, India, 1997, p. 113.
77. Khan, A.K., Akhtar, S., and Mahtab, H., Treatment of diabetes mellitus with Coccinia indica,
Br. Med. J., 280(6220), 1044, 1980.
78. Singh, N., Singh, S.P., Vrats, S., et al., A study on the anti-diabetic activity of Coccina indica in
dogs, Indian J. Med. Sci., 39, 27, 1985.
79. Kumar, G.P., Sudheesh, S., and Vijayalakshmi, N.R., Hypoglycemic effect of Coccinia indica:
mechanism of action, Planta Med., 59(4), 330, 1993.
80. Chandrasekar, B., Mukherjee, B., and Mukherjee, S.K., Blood sugar lowering potentiality of
selected Cucurbitaceae plants of Indian origin, Indian J. Med. Res., 90, 300, 1998.
81. Platel, K. and Srinivasan, K., Plant foods in the management of diabetes mellitus: vegetables
as potential hypoglycemic agents, Nahrung, 41(2), 68, 1997.
82. Ivorra, M.D., Paya, M., and Villar, A., A review of natural products and plants as potential
antidiabetic drugs, J. Ethnopharmacol., 27, 243, 1989.
83. Bailey, C.J. and Day, C., Traditional plant medicines as the treatments for diabetes, Diabetes
Care, 12(8), 553, 1989.
84. Ajgaonkar, S.S., Herbal drugs in the treatment of diabetes: a review, Int. Diabetes Fed. Bull., 24,
10, 1979.
85. Brahmchari, H.D. and Augusti, K.T., Orally effective hypoglycemic principles from Coccina
indica, J. Pharm. Pharmacol., 15, 411, 1963.
86. Azad Khan, A.K., Akhtar, S., and Mahtab, H., Coccina indica in the treatment of patients with
diabetes mellitus, Bangladesh Med. Res. Counc. Bull., 5(2), 60, 1079.
87. Kamble, S.M., Kamlakar, P.L., Vaidya, S., et al., Influence of Coccina indica on certain enzymes
in glycolytic and lipolytic pathway in human diabetes, Indian J. Med. Sci., 52(4), 143, 1998.
88. Chatterjee, A. and Pakrashi, S.C., The Treatise on Indian Medicinal Plants, Vol. 2, Publications
and Information Directorate, New Delhi, India, 1992, p. 115.
89. Shah, D.S., A preliminary study of the hypoglycemic action of heartwood of Pterocarpus
marsupium roxb., Indian J. Med. Res., 55(2), 166, 1967.
90. Sheehan, E.W., Zemaitis, M.A., Slatkin, D.J., et al., A constituent of Pterocarpus marsupium,
(-)-epicatechin, as a potential antidiabetic agent, J. Nat. Prod., 46(2), 232, 1983.

91. Ahmad, F., Khalid, P., Khan, M.M., et al., Hypoglycemic activity of Pterocarpus marsupium
wood, J. Ethnopharmacol., 35(1), 71, 1991.
92. Manickam, M., Ramanathan, M., Jahromi, M.A., et al., Antihyperglycemic activity of phenolics
from Pterocarpus marsupium, J. Nat. Prod., 60(6), 609, 1997.
93. Indian Council for Medical Research (ICMR), Collaborating Centers, New Delhi, Flexible dose
open trial of Vijayasar in cases of newly-diagnosed non-insulin-dependent diabetes mellitus,
Indian J. Med. Res., 108, 24, 1998.
94. Kameswara Rao, B., Giri, R., Kesavulu, M.M., et al., Effect of oral administration of bark extracts
of Pterocarpus santalinus L. on blood glucose level in experimental animals, J. Ethnopharmacol.,
74(1), 69, 2001.
95. Nagaraju, N., Prasad, M., Gopalakrishna, G., et al., Blood sugar lowering effect of Pterocarpus
santalinus (red sandal) wood extract in different rat models, Int. J. Pharmacognosy, 29(2), 141,
1991.
96. Chatterjee, A. and Pakrashi, S.C., The Treatise on Indian Medicinal Plants, Publications & Information
Directorate, New Delhi, India, 1991, p. 39.
97. Augusti, K.T., Hypoglycemic action of bengalenoside, a glucoside isolated from Ficus bengalensis
Linn, in normal and alloxan diabetic rats, Indian J. Physiol. Pharmacol., 19(4), 218, 1975.
98. Kumar, R.V. and Augusti, K.T., Antidiabetic effect of leucocyanidin derivative isolated from
the bark of Ficus bengalensis Linn, Indian J. Biochem. Biophys., 26(6), 400, 1989.
99. Acherkar, S., Kaklij, G.S., Pote, M.S., et al., Hypoglycemic activity of Eugenia jambolana and
Ficus bengalensis: mechanism of action, In Vivo, 5(2), 143, 1991.
100. Cherian, S., Kumar, R.V., Augusti, K.T., et al., Antidiabetic effect of a glycoide of pelargonidin
isolated from the bark of Ficus bengalensis Linn., Indian J. Biochem. Biophys., 29(4), 380, 1992.
101. Cherian, S. and Augusti, K.T., Antidiabetic effects of a glycoside of leucopelargonidin isolated
from Ficus bengalensis Linn., Indian J. Exp. Biol., 31(1), 26, 1993.
102. Augusti, K.T., Daniel, R.S., Cherian, S., et al., Effect of leucopelargonin derivative from Ficus
bengalensis Linn. on diabetic dogs, Indian J. Med. Res., 99, 82, 1994.
103. Geetha, B.S., Mathew, B.C., and Augusti, K.T., Hypoglycemic effects of leucodelphinidin
derivative isolated from Ficus bengalensis (Linn.), Indian J. Physiol. Pharmacol., 38(3), 220, 1994.
104. Chowdhary, D.P. and Dua, M., Hypoglycemic effect of a coded formulation: Aysuh-82, J. Res.
Ayurveda and Siddha, 19(3–4), 107, 1998.
105. Pandey, V.N., Rajagopalan, S.S., and Chowdhary, D.P., An effective Ayruvedic hypoglycemic
formulation, J. Res. Ayurveda and Siddha, 16(1–2), 1, 1995.
106. Sircar, A.R., Ahuja, R.C., Natu, S.M., et al., Hypoglycemic, hypolipidemic and general beneficial
effects of an herbal mixture MA-471, Altern. Ther. Clin. Pract., 3(5), 26, 1996.
107. Sankar, V.R. and Aggarwal, M.P., Clinical studies of abraga (mica) chendooram in the management
of diabetes mellitus (neerazhivu), J. Res. Ayurveda and Siddha, 9(1–2), 38, 1988.
108. Shankar, R. and Singhal, R.K., Clinical studies of the effect of abraga (mica) chendooram in
the treatment of diabetes mellitus (neerazhivu), J. Res. Ayurveda and Siddha, 16(3–4), 108, 1995.
109. Maji, D. and Singh, A.K., Clinical trial of D-400, a herbomineral preparation in diabetes
mellitus, J. Diabetic Assoc. India, 35(1), 1, 1995.
110. Shankar, R. and Singhal, R.K., Clinical assessement of the effects of sandana (sandal) podi-a
in the treatment of diabetes mellitus (neerazhiv), J. Res. Ayurveda and Siddha, 15(3–4), 89, 1994.
111. Sivaprakasam, K., Rao, K.K., Yasodha, R., et al., Siddha remedy for diabetes mellitus, J. Res.
Ayurveda and Siddha, 5(1–4), 25, 1984.
112. Kumar, N. and Kumar, A., A clinical trial of M-93 compound in the management of madhumeha
(diabetes mellitus), J. Res. Ayurveda and Siddha, 16(3–4), 102, 1995.
113. Wadood, A., Wadood, N., and Shah, S.A., Effects of Acacia arabica and Caralluma edulis on
blood glucose levels of normal and alloxan diabetic rabbits, J. Pak. Med. Assoc., 39(8), 208, 1989.
114. Akhtar, M.S. and Iqbal, J., Evaluation of the hypoglycaemic effect of Achyranthes aspera in
normal and alloxan-diabetic rabbits, J. Ethnopharmacol., 31(1), 49, 1991.
115. Karunanayake, E.H., Welihinda, J., Sirimanne, S.R., et al., Oral hypoglycaemic activity of some
medicinal plants of Sri Lanka, J. Ethnopharmacol., 11(2), 223, 1984.

116. Sachdewa, A., Raina, D., Srivastava, A.K., et al., Effect of Aegle marmelos and Hibiscus rosa
sinensis leaf extract on glucose tolerance in glucose induced hyperglycemic rats (Charles
foster), J. Environ. Biol., 22(1), 53, 2001.
117. Mathew, P.T. and Augusti, K.T., Hypoglycaemic effects of onion, Allium cepa Linn. on diabetes
mellitus — a preliminary report, Indian J. Physiol. Pharmacol., 19(4), 213, 1975.
118. Roman-Ramos, R., Flores-Saenz, J.L., and Alarcon-Aguilar, F.J., Anti-hyperglycemic effect of
some edible plants, J. Ethnopharmacol., 48(1), 25, 1995.
119. Babu, P.S. and Srinivasan, K., Influence of dietary capsaicin and onion on the metabolic
abnormalities associated with streptozotocin induced diabetes mellitus, Mol. Cell. Biochem.,
175(1–2), 49, 1997.
120. Sheela, C.G. and Augusti, K.T., Antidiabetic effects of S-allyl cysteine sulphoxide isolated from
garlic Allium sativum Linn., Indian J. Exp. Biol., 30(6), 523, 1992.
121. Sheela, C.G., Kumud, K., and Augusti, K.T., Anti-diabetic effects of onion and garlic sulfoxide
amino acids in rats, Planta Med., 61(4), 356, 1995.
122. Augusti, K.T. and Sheela, C.G., Antiperoxide effect of S-allyl cysteine sulfoxide, an insulin
secretagogue, in diabetic rats, Experientia, 52(2), 115, 1996.
123. Kumar, G.R. and Reddy, K.P., Reduced nociceptive responses in mice with alloxan induced
hyperglycemia after garlic (Allium sativum Linn.) treatment, Indian J. Exp. Biol., 37(7), 662,
1999.
124. Kasuga, S., Ushijima, M., Morihara, N., et al., Effect of aged garlic extract (AGE) on hyperglycemia
induced by immobilization stress in mice, Nippon Yakurigaku Zasshi, 114(3), 191,
1999.
125. Patumraj, S., Tewit, S., Amatyakul, S., et al., Comparative effects of garlic and aspirin on
diabetic cardiovascular complications, Drug Delivery, 7(2), 91, 2000.
126. Ghannam, N., Kingston, M., Al-Meshaal, I.A., et al., The antidiabetic activity of aloes: preliminary
clinical and experimental observations, Horm. Res., 24(4), 288, 1986.
127. Al-Awadi, F.M. and Gumaa, K.A., Studies on the activity of individual plants of an antidiabetic
plant mixture, Acta Diabetol. Lat., 24(1), 37, 1987.
128. Ajabnoor, M.A., Effect of aloes on blood glucose levels in normal and alloxan diabetic mice,
J. Ethnopharmacol., 28(2), 215, 1990.
129. Al-Awadi, F., Fatania, H., and Shamte, U., The effect of a plants mixture extract on liver
gluconeogenesis in streptozotocin induced diabetic rats, Diabetes Res., 18(4), 163, 1991.
130. Okyar, A., Can, A., Akev, N., et al., Effect of Aloe vera leaves on blood glucose level in type
I and type II diabetic rat models, Phytother. Res., 15(2), 157, 2001.
.131. Zhang, X.F. and Tan, B.K., Anti-diabetic property of ethanolic extract of Andrographis paniculata
in streptozotocin-diabetic rats, Acta Pharmacol. Sin., 21(12), 1157, 2000.
132. Zhang, X.F. and Tan, B.K., Antihyperglycaemic and anti-oxidant properties of Andrographis
paniculata in normal and diabetic rats, Clin. Exp. Pharmacol. Physiol., 27(5–6), 358, 2000.
133. Sen, P., Mediratta, P.K., and Ray, A., Effects of Azadirachta indica A Juss on some biochemical,
immunological and visceral parameters in normal and stressed rats, Indian J. Exp. Biol., 30
(12), 1170, 1992.
134. Chattopadhyay, R.R., Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf
extract. IV, Gen. Pharmacol., 27(3), 431, 1996.
135. Chattopadhyay, R.R., A comparative evaluation of some blood sugar lowering agents of plant
origin, J. Ethnopharmacol., 67(3), 367, 1999.
136. Khosla, P., Bhanwra, S., Singh, J., et al., A study of the hypoglycaemic effect of Azadirachta
indica (Neem) in normal and alloxan diabetic rabbits, Indian J. Physiol. Pharmacol., 44(1), 69,
2000.
137. Saleem, R., Ahmad, M., Hussain, S.A., et al., Hypotensive, hypoglycaemic and toxicological
studies on the flavonol C-glycoside shamimin from Bombax ceiba, Planta Med., 65(4), 331, 1999.
138. Sharma, S.R., Dwivedi, S.K., and Swarup, D., Hypoglycaemic, antihyperglycaemic and hypolipidemic
activities of Caesalpinia bonducella seeds in rats, J. Ethnopharmacol., 58(1), 39, 1997.

139. Yoshikawa, M., Murakami, T., Kishi, A., et al., Medicinal flowers. III. Marigold. (1): hypoglycemic,
gastric emptying inhibitory, and gastroprotective principles and new oleanane-type
triterpene oligoglycosides, calendasaponins A, B, C, and D, from Egyptian Calendula officinalis,
Chem. Pharm. Bull. (Tokyo), 49(7), 863, 2001.
140. Yadav, P., Sarkar, S., and Bhatnagar, D., Action of Capparis decidua against alooxan-induced
oxidative stress and diabetes in rat tissues, Pharmacol. Res., 36(3), 221, 1997.
141. Tolan, I., Ragoobirsingh, D., and Morrison, E.Y., The effect of capsaicin on blood glucose,
plasma insulin levels and insulin binding in dog models, Phytother. Res., 15(5), 391, 2001.
142. Esposito Avella, M., Diaz, A., de Gracia, I., et al., Evaluation of traditional medicine: effects
of Cajanus cajan L. and of Cassia fistula L. on carbohydrate metabolism in mice, Rev. Med.
Panama, 16(1), 39, 1991.
143. Singh, S.N., Vats, P., Suri, S., et al., Effect of an antidiabetic extract of Catharanthus roseus on
enzymic activities in streptozotocin induced diabetic rats, J. Ethnopharmacol., 76(3), 269, 2001.
144. Grindley, P.B., Omoruyi, F.O., Asemota, H.N., et al., Effect of yam (Dioscorea cayenensis) and
dasheen (Colocassia esculenta) extracts on the kidney of streptozotocin-induced diabetic rats,
Int. J. Food Sci. Nutr., 52(5), 429, 2001.
145. Sharma, A.L., Sapru, H.N., and Chowdhury, N.K., Hypoglycaemic action of Cryptostegia grandiflora
R.Br.. in rabbits, Indian J. Med. Res., 55(12), 1277, 1967.
146. Srivastava, A., Longia, G.S., Singh, S.P., et al., Hypoglycaemic and hypolipaemic effects of
Cyamopsis tetragonoloba (guar) in normal and diabetic guinea pigs, Indian J. Physiol. Pharmacol.,
31(2), 77, 1987.
147. Frias, A.C. and Sgarbieri, V.C., Guar gum effects on food intake, blood serum lipids and glucose
levels of Wistar rats, Plant Foods Hum. Nutr., 53(1), 15, 1998.
148. Teixeira, C.C., Pinto, L.P., Kessler, F.H., et al., The effect of Syzygium cumini (L.) skeels on postprandial
blood glucose levels in non-diabetic rats and rats with streptozotocin-induced diabetes
mellitus, J. Ethnopharmacol., 56(3), 209, 1997.
149. Achrekar, S., Kaklij, G.S., Pote, M.S., et al., Hypoglycemic activity of Eugenia jambolana and
Ficus bengalensis: mechanism of action, In Vivo, 5(2), 143, 1991.
150. Grover, J.K., Vats, V., Rathi, S.S., et al., Traditional Indian anti-diabetic plants attenuate progression
of renal damage in streptozotocin induced diabetic mice, J. Ethnopharmacol., 76(3),
233, 2001.
151. Vikrant, V., Grover, J.K., Tandon, N., et al., Treatment with extracts of Momordica charantia and
Eugenia jambolana prevents hyperglycemia and hyperinsulinemia in fructose fed rats, J. Ethnopharmacol.,
76(2), 139, 2001.
152. Grover, J.K., Vats, V., and Rathi, S.S., Anti-hyperglycemic effect of Eugenia jambolana and
Tinospora cordifolia in experimental diabetes and their effects on key metabolic enzymes involved
in carbohydrate metabolism, J. Ethnopharmacol., 73(3), 461, 2000.
153. Serraclara, A., Hawkins, F., Perez, C., et al., Hypoglycemic action of an oral fig-leaf decoction
in type-I diabetic patients, Diabetes Res. Clin. Pract., 39(1), 19, 1998.
154. Canal, J.R., Torres, M.D., Romero, A., et al., A chloroform extract obtained from a decoction
of Ficus carica leaves improves the cholesterolaemic status of rats with streptozotocin-induced
diabetes, Acta Physiol. Hung., 87(1), 71, 2000.
155. Desai, A.C. and Bhide, M.B., Hypoglycaemic activity of Hamiltonia suaveolen, Indian J. Med.
Res., 81, 86, 1985.
156. Sachdewa, A. and Khemani, L.D., A preliminary investigation of the possible hypoglycemic
activity of Hibiscus rosa-sinensis, Biomed. Environ. Sci., 12(3), 222, 1999.
157. Sachdewa, A., Raina, D., Srivastava, A.K., et al., Effect of Aegle marmelos and Hibiscus rosa
sinensis leaf extract on glucose tolerance in glucose induced hyperglycemic rats (Charles
foster), J. Environ. Biol., 22(1), 53, 2001.
158. Sachdewa, A., Nigam, R., and Khemani, L.D., Hypoglycemic effect of Hibiscus rosa sinensis L.
leaf extract in glucose and streptozotocin induced hyperglycemic rats, Indian J. Exp. Biol., 39(3),
284, 2001.

159. Tripathi, Y.B. and Chaturvedi, P., Assessment of endocrine response of Inula racemosa in relation
to glucose homeostasis in rats, Indian J. Exp. Biol., 33(9), 686, 1995.
160. Aderibigbe, A.O., Emudianughe, T.S., and Lawal, B.A., Antihyperglycaemic effect of Mangifera
indica in rat, Phytother. Res., 13(6), 504, 1999.
161. Aderibigbe, A.O., Emudianughe, T.S., and Lawal, B.A., Evaluation of the antidiabetic action
of Mangifera indica in mice, Phytother. Res., 15(5), 456, 2001.
162. Rao, B.K., Kesavulu, M.M., and Appa Rao, C., Antidiabetic and hypolipidemic effects of
Momordica cymbalaria Hook. Fruit powder in alloxan-diabetic rats, J. Ethnopharmacol., 67(1),
103, 1999.
163. Rao, B.K., Kesavulu, M.M., and Apprao, C., Antihyperglycemic activity of Momordica cymbalaria
in alloxan diabetis rats, J. Ethnopharmacol., 78(1), 67, 2001.
164. Akhtar, M.S., Qureshi, A.Q., and Iqbal, J., Antidiabetic evaluation of Mucuna pruriens, Linn
seeds, J. Pak. Med. Assoc., 40(7), 147, 1990.
165. Khan, B.A., Abraham, A., and Leelamma, S., Hypoglycemic action of Murraya koenigii (curry
leaf) and Brassica juncea (mustard): mechanism of action, Indian J. Biochem. Biophys., 32(2), 106,
1995.
166. Alarcon-Aguilara, F.J., Roman-Ramos, R., Perez-Gutierrez, S., et al., Study of the anti-hyperglycemic
effect of plants used as antidiabetics, J. Ethnopharmacol., 61(2), 101, 1998.
167. Pari, L. and Maheswari, J.U., Hypoglycaemic effect of Musa sapientum L. in alloxan-induced
diabetic rats, J. Ethnopharmacol., 68(1–3), 321, 1999.
168. Pari, L. and Umamaheswari, J., Antihyperglycaemic activity of Musa sapientum flowers: effect
on lipidperoxidation in alloxan diabetic rats, Phytother. Res., 14(2), 136, 2000.
169. Mukherjee, P.K., Saha, K., Pal, M., et al., Effect of Nelumbo nucifera rhizome extract on blood
sugar level in rats, J. Ethnopharmacol., 58(3), 207, 1997.
170. Chattopadhyay, R.R., Hypoglycemic effect of Ocimum sanctum leaf extract in normal and
streptozotocin diabetic rats, Indian J. Exp. Biol., 31(11), 891, 1993.
171. Agrawal, P., Rai, V., and Singh, R.B., Randomized placebo-controlled, single blind trial of holy
basil leaves in patients with noninsulin-dependent diabetes mellitus, Int. J. Clin. Pharmacol.
Ther., 34(9), 406, 1996.
172. Rai, V., Iyer, U., and Mani, U.V., Effect of Tulasi (Ocimum sanctum) leaf powder supplementation
on blood sugar levels, serum lipids and tissue lipids in diabetic rats, Plant Foods Hum. Nutr.,
50(1), 9, 1997.
173. Srivastava, A. and Joshi, L.D., Effect of feeding black gram (Phaseolus mungo) on serum lipids
of normal & diabetic guineapigs, Indian J. Med. Res., 92, 383, 1990.
174. Mani, U.V., Pradhan, S.N., Mehta, N.C., et al., Glycaemic index of conventional carbohydrate
meals, Br. J. Nutr., 68(2), 445, 1992.
175. Srividya, N. and Periwal, S., Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus
amarus, Indian J. Exp. Biol., 33(11), 861, 1995.
176. Higashino, H., Suzuki, A., Tanaka, Y., et al., Hypoglycemic effects of Siamese Momordica
charantia and Phyllanthus urinaria extracts in sterptozocin-induced diabetic rats (the 1st
report), Nippon Yakuraigaku Zasshi, 100(5), 415, 1992.
177. Joy, K.L. and Kuttan, R., Anti-diabetic activity of Picrorrhiza kurroa extract, J. Ethnopharmacol.,
67(2), 143, 1999.
178. Miura, T. and Kato, A., the difference in hypoglycemic action between polygonati rhizoma
and polygonati officinalis rhizoma, Biol. Pharm. Bull., 18(11), 1605, 1995.
179. Cheng, J.T. and Yang, R.S., Hypoglycemic effect of guava juice in mice and human subjects,
Am. J. Chin. Med., 11(1–4), 74, 1983.
180. Kameswara Rao, B., Giri, R., Kesavulu, M.M., et al., Effect of oral administration of bark extracts
of Pterocarpus santalinus L. on blood glucose level in experimental animals, J. Ethnopharmacol.,
74(1), 69, 2001.
181. Jafri, M.A., Aslam, M., Javed, K., et al., Effect of Punica granatum Linn. (flowers) on blood
glucose level in normal and alloxan-induced diabetic rats, J. Ethnopharmacol., 70(3), 309, 2000.
182. Sekar, B.C., Mukherjee, B., Chakravarti, R.B., et al., Effect of different fractions of Swertia
chirayita on the blood sugar level of albino rats, J. Ethnopharmacol., 21(2), 175, 1987.

183. Chandrasekar, B., Bajpai, M.B., and Mukherjee, S.K., Hypoglycemic activity of Swertia chirayita
(Roxb ex Flem) Karst, Indian J. Exp. Biol., 28(7), 616, 1990.
184. Bajpai, M.B., Asthana, R.K., Sharma, N.K., et al., Hypoglycemic effect of swerchirin from the
hexane fraction of Swertia chirayita, Planta Med., 57(2), 102, 1991.
185. Saxena, A.M., Bajpai, M.B., and Mukherjee, S.K., Swerchirin induced blood sugar lowering of
streptozotocin treated hyperglycemic rats, Indian J. Exp. Biol., 29(7), 674, 1991.
186. Saxena, A.M., Murthy, P.S., and Mukherjee, S.K., Mode of action of three structurally different
hypoglycemic agents: a comparative study, Indian J. Exp. Biol., 34(4), 351, 1996.
187. Saxena, A.M., Bajpai, M.B., Murthy, P.S., et al., Mechanism of blood sugar lowering by a
swerchirin-containing hexane fraction (SWI) of Swertia chirayita, Indian J. Exp. Biol., 31(2), 178,
1993.
188. Rao, B.K. and Rao, C.H., Hypoglycemic and antihyperglycemic activity of Syzygium alternifolium
(Wt.) Walp. seed extracts in normal and diabetic rats, Phytomedicine, 8(2), 88, 2001.
189. Lozoya-Meckes, M. and Mellado-Campos, V., Is the Tecoma stans infusion an antidiabetic
remedy? J. Ethnopharmacol., 14(1), 1, 1985.
190. Roman-Ramos, R., Flores-Saenz, J.L., Partida-Hernandez, G., et al., Experimental study of the
hypoglycemic effect of some antidiabetic plants, Arch. Invest. Med. (Mexico), 22(1), 87, 1991.
191. Fort, D.M., Rao, K., Jolad, S.D., et al., Antihyperglycemic activity of Teramus labialis (Fabaceae),
Phytomedicine, 6(6), 465, 2000.
192. Wadood, N., Wadood, A., and Shah, S.A., Effect of Tinospora cordifolia on blood glucose and
total lipid levels of normal and alloxan-diabetic rabbits, Planta Med., 58(2), 131, 1992.
193. Stanely Mainzen Prince, P. and Menon, V.P., Antioxidant action of Tinospora cordifolia root
extract in alloxan diabetic rats, Phytother. Res., 15(3), 213, 2001.
194. Noor, H. and Ashcroft, S.J., Antidiabetic effects of Tinospora crispa in rats, J. Ethnopharmacol.,
27(1–2), 149, 1989.
195. Noor, H., Hammonds, P., Sutton, R., et al., The hypoglycaemic and insulinotropic activity of
Tinospora crispa: studies with human and rat islets and HIT-T15 B cells, Diabetologia, 32(6), 354,
1989.
196. Noor, H. and Ashcroft, S.J., Pharmacological characterisation of the antihyperglycaemic properties
of Tinospora crispa extract, J. Ethnopharmacol., 62(1), 7, 1998.
197. Chattopadhyay, R.R., Sarkar, S.K., Ganguly, S., et al., Hypoglycemic and antihyperglycemic
effect of leaves of Vinca rosea linn, Indian J. Physiol. Pharmacol., 35(3), 145, 1991.
198. Andallu, B. and Radhika, B., Hypoglycemic, diuretic and hypocholesterolemic effect of winter
cherry (Withania somnifera, Dunal) root, Indian J. Exp. Biol., 38(6), 607, 2000.

 





Om Tat Sat
                                                        
(Continued...) 


(My humble salutations to H H Maharshi ji,  Brahmasri Sreeman Lakshmi Chandra Mishra ji and other eminent medical scholars and doctors   for the collection)

0 comments:

Post a Comment